From 1999 to 2009, Art J. Samberg served as Chairman, Chief Executive Officer, and Managing Director of one of the most successful hedge funds of all time, Pequot Capital Management Inc. In 2000 and 2001, PCMI managed over $17 billion, which, at the time, was the largest fund in the world. Throughout the sharp downturn in the markets in the late 1990s, now known as the bursting of the "Tech Bubble," PCMI was recognized as an industry leader under the direction of Arthur J. Samberg. In May of 2009, PCMI was dissolved, allowing Art Samberg to turn his efforts to philanthropy and managing the family funds through Hawkes Financial, LLC.

In 2006 Art Samberg made a $25 million donation to Columbia Business School, where he received his MBA in 1967. The donation served to endow 13 new professorships as well as fund many new positions across multiple disciplines at the university.

Art J. Samberg holds a seat on the boards of College Summit, Historic Hudson Valley, Jacob Burns Film Center, Jazz at Lincoln Center, and the UJA Federation of New York.

In 2011, The New York Hedge Fund Roundtable invited Art Samberg to join a heated debate on "Long-Only vs. Alternative Investing: Is There a Place for Both?" Arthur J. Samberg’s passionate participation helped the group advance its mission to create a forum for thoughtful leadership geared toward progressing the ethics of the industry into the future.